Issue 22, 1986

Synthesis and biological evaluation of a trichothecene epi-epoxide, 3α,4β,15-triacetoxy-12,13-epi-epoxytrichothec-9-ene

Abstract

In order to provide additional insight into the mode of action of the trichothecene mycotoxins, one of the first semi-synthetic trichothecene epi-epoxides (8) has been prepared; in dramatic contrast to its natural isomer (9), this compound proved to be devoid of significant biological activity.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1986, 1642-1643

Synthesis and biological evaluation of a trichothecene epi-epoxide, 3α,4β,15-triacetoxy-12,13-epi-epoxytrichothec-9-ene

E. W. Colvin and S. Cameron, J. Chem. Soc., Chem. Commun., 1986, 1642 DOI: 10.1039/C39860001642

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