Studies on the synthesis of the antitumour agent CC-1065. Synthesis of PDE I and PDE II, inhibitors of cyclic adenosine-3′,5′-monophosphate phosphodiesterase
Abstract
The 3,3′-bipyrrole approach to the synthesis of highly functionalized indoles has been used to construct the B and C components of CC-1065 in the form of PDE I (2) and PDE II (3) respectively.