Chloromethyl trimethylsilylmethyl sulphide as a parent thiocarbonyl ylide synthon. A simple synthesis of dihydro- and tetrahydro-thiophenes
Abstract
Chloromethyl trimethylsilylmethyl sulphide acts as a parent thiocarbonyl ylide synthon and reacts stereospecifically with activated alkenes and alkynes, catalysed by caesium fluoride, in acetonitrile at room temperature to give tetrahydro- and dihydro-thiophene derivatives in good yields.