Theoretical calculations of conformational energies of dihydropyridine calcium agonists and antagonists show that there is a conformation which can be adopted by agonists which is not available to antagonists, and is achievable with difficulty by a partial agonist; on the basis of these differences a model for the receptor can be hypothesised.
M. Mahmoudian and W. G. Richards, J. Chem. Soc., Chem. Commun., 1986, 739 DOI: 10.1039/C39860000739
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