Heptafluoro-p-tolyl as a selective protecting group for the enone function of androst-4-ene-3,17-dione: application to the preparation of deuterium-labelled testosterone
Abstract
Octafluorotoluene reacts with the enone function of androst-4-ene-3,17-dione in the presence of caesium fluoride to give specifically a 3,5-dienol ether which has been used to prepare deuterium-labelled testosterone.