The trypanosomatid metabolite trypanothione [N1,N8-bis(glutathionyl)spermidine] and its biosynthetic co-metabolites the isomeric N1- and N8-mono-glutathionylspermidines have been synthesised by a mild route which involves coupling of glycinyl-spermidine derivatives to a functionally protected γ-glutamylcysteine dipeptide.
G. B. Henderson, P. Ulrich, A. H. Fairlamb and A. Cerami, J. Chem. Soc., Chem. Commun., 1986, 593 DOI: 10.1039/C39860000593
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