A Macrocyclic spiro-lactam is synthesised which closely resembles the spiro system proposed as a biosynthetic intermediate for uro'gen-III; this spiro-lactam powerfully inhibits cosynthetase, the enzyme responsible for forming uro'gen-III.
W. M. Stark, G. J. Hart and A. R. Battersby, J. Chem. Soc., Chem. Commun., 1986, 465 DOI: 10.1039/C39860000465
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