Reaction of benzyl 6α-(methylthio)-6β-(phenoxyacetamido)penicillanate with N-hydroxysuccinimide catalysed by silver(I) acetate afforded the stable 6α-(succinimido-oxy) dervative; this species on reaction with various nucleophiles gave a range of 6α-substituted penicillins, including some not directly available from the 6α-(methylthio) compound.
A. V. Stachulski, J. Chem. Soc., Chem. Commun., 1986, 401 DOI: 10.1039/C39860000401
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