Sensitive adsorptive stripping voltammetric measurements of antihypertensive drugs

Abstract

Controlled adsorptive accumulation of reserpine, rescinnamine and hydralazine on carbon electrodes provides the basis for sensitive stripping measurement schemes for these compounds. Cyclic voltammetry is used to explore the interfacial and redox behaviours. The detection limits are reserpine, 2 × 10^–9M, rescinnamine, 3 × 10^–9M, and hydralazine, 1 × 10^–8M. The adsorptive stripping response is evaluated with respect to various experimental conditions. Exchange to a blank solution corrects for major interferences. The relative standard deviation at the sub-micromolar level ranges from 5 to 9%. Applicability to measurements in urine is illustrated.