The circular dichroism of a t-ribonucleic acid and its iodinated derivative in aqueous solution

Abstract

The circular dichroism (c.d.) of a t-ribonucleic acid (t-RNA) and its iodinated derivative indicate that the iodination procedure does not significantly alter the helical conformation of the polynucleotide. This is further confirmed by c.d. studies of the effects of pH and the addition of ethylene glycol (a known destacking agent) upon the helical conformation of the t-RNA and the iodinated RNA.