Kinetics of the detritiation of a series of 4- and 5-substituted 2-([3H]acetyl)thiophenes

Abstract

A series of 4- and 5-substituted 2-([³H]acetyl)thiophenes have been prepared and the kinetics of the hydroxide-catalysed detritiation studied at 25.0 °C. The second-order detritiation rate constants parallel those observed for the corresponding meta- and para-substituted acetophenones but as the reaction constant ρ is higher (1.61) the range of reactivity is much wider than that witnessed for the acetophenones.