Liquid chromatographic optical resolution of 2,2′-spirobibenz[e]indan derivatives and absolute stereochemistry as determined by the c.d. exciton chirality method

Abstract

2,2′-Spirobibenz[e]indan derivatives, (1) and (2), have been synthesized and optically resolved by means of liquid chromatography using a column with a chiral stationary phase of (+)-poly-(triphenylmethyl methacrylate); the absolute stereochemistry of each enantiomer was unambiguously determined by the c.d. exciton chirality method.