A mild and highly efficient method for the reduction of the 5,6-double bond of N-alkylated uracils with lithium tri-s-butylborohydride gives the corresponding 5,6-dihydro derivatives. The method can also be used for alkylation of the 5-position of N-alkyluracils to give 5-alkyl-5,6-dihydrouracil derivatives.
N. G. Kundu, S. Sikdar, R. P. Hertzberg, S. A. Schmitz and S. G. Khatri, J. Chem. Soc., Perkin Trans. 1, 1985, 1295 DOI: 10.1039/P19850001295
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