Issue 0, 1985

Evaluation of phosphinic acid derivatives as reagents for amine protection in peptide synthesis

Abstract

The results of a kinetic study of the acid-catalysed methanolysis of a series of N-(2-phenyl-ethyl)phosphinamides incorporating selected substituents on phosphorus have been evaluated in order to define the optimum reagent and conditions for amine protection of α-amino acids during peptide synthesis.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1985, 1217-1226

Evaluation of phosphinic acid derivatives as reagents for amine protection in peptide synthesis

R. Ramage, B. Atrash, D. Hopton and M. J. Parrott, J. Chem. Soc., Perkin Trans. 1, 1985, 1217 DOI: 10.1039/P19850001217

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