Thiathromboxane analogues (2) and (19) have been prepared by an extremely short and efficient synthetic route which can also be employed to make simple 2,3-dialkylated thian-4-ones. The cornerstone of the synthetic strategy is the organocopper conjugate addition – enolate alkylation reactions of 3-methoxycarbonyl-5,6-dihydrothiin-4-one (1b).
S. Lane, S. J. Quick and R. J. K. Taylor, J. Chem. Soc., Perkin Trans. 1, 1985, 893 DOI: 10.1039/P19850000893
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