Issue 5, 1985
From the journal:

Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases

The inclusion of haloperidol and trifluperidol by α- and γ-cyclodextrins. A 19F nuclear magnetic resonance study

Dino L. Pisaniello,   Stephen F. Lincoln  and  John H. Coates  

Abstract

The complexation of haloperidol (HP) and trifluperidol (TFP) by α-cyclodextrin (α-CD) and γ-cyclodextrin (γ-CD) has been studied by 19F n.m.r. at 295 K. Complexation at the m-CF3(A) and p-F (B) sites of TFP is characterised by stability constants KA= 50±2 mol–1 dm3 and KB= 9±4 mol–1 dm3 in the presence of α-CD and KA= 15±3 mol–1 dm3 and KB= 28±9 mol–1 dm3 in the presence of γ-CD. Similar observations are made for haloperidol.

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Article information

DOI
https://doi.org/10.1039/F19858101247
Article type
Paper

J. Chem. Soc., Faraday Trans. 1, 1985,81, 1247-1253

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The inclusion of haloperidol and trifluperidol by α- and γ-cyclodextrins. A 19F nuclear magnetic resonance study

D. L. Pisaniello, S. F. Lincoln and J. H. Coates, J. Chem. Soc., Faraday Trans. 1, 1985, 81, 1247 DOI: 10.1039/F19858101247

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