Studies on the anti-tumour activity of di- and tri-organotin(IV) complexes of amino acids and related compounds, of 2-mercaptoethanesulphonate, and of purine-6-thiol

Abstract

The anti-tumour activity of 20 complexes of di- and tri-organotin(IV) has been tested in vivo in P-388 leukaemic mice. The complexes include SnPh₂(CysOS)[CysOS =L-cysteinate(2–)], SnR₂(Pen)(H₂Pen =DL-penicillamine; R = Me, Buⁿ, or Ph), the anions [SnR₂(SCH₂CH₂SO₃)₂]^2–(R = Me, Et, Buⁿ, or Ph), SnMe₂(PhCO-GlyO)₂(PhCO-GlyO =N-benzoylglycinate), N-substituted glycinates of SnR₃(R = Me or Buⁿ), SnBuⁿ₂(put)₂(Hput = purine-6-thiol), SnR₃(put)(R = Me, Buⁿ, or Ph), and (SnPh₃)₃(put)₂. The complex tris(L-cysteinato) bismuth (III) has been investigated also, for comparison purposes. The results are discussed in connection with the structural characteristics, available to date, of the complexes in solution phases.