Stereocontrolled synthesis of four possible stereoisomers of vicinal diol derivatives via relative 1,2-asymmetric induction. Preparation of optically active exo- and endo-brevicomin

Abstract

Four possible stereoisomers of vicinal diol derivatives were synthesized stereoselectively by nucleophilic addition to α-alkoxy-β-trimethylsily-βγ-unsaturated carbonyl compounds and this reaction was applied to the synthesis of exo and endo-brevicomin.