Intramolecular Diels–Alder reaction of trienes (8) gives the octahydroisoquinolones (10) which are readily converted into the biologically-active (12), a substructure of morphine.
S. Handa, K. Jones, C. G. Newton and D. J. Williams, J. Chem. Soc., Chem. Commun., 1985, 1362 DOI: 10.1039/C39850001362
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