The synthesis of optically active tetrahydropyrans by the addition of a stabilised Witting reagent to pyranose sugars
Abstract
The addition of the phosphonate–sulphone (8) to the carbohydrates (9) and (10) gave the tetrehydropyrans (11) and (12) as mixtures of α- and β-isomers; treatment of the mixture with sodium hydride gave the purer β-isomers.