A short synthesis of hirsutene using the de Mayo reaction
Abstract
A short synthesis of the fungal metabolic hirsutene is described in which the key steps are photochemical cycloaddition of the enol of 5,5-dimethylcyclohexane-1,3-dione to 2-methylcyclopent-2-enol, followed by low-valent titanium reduction of the silylated adducts.