Issue 16, 1985

Ring opening of N-tosylhistamine with di-t-butyl pyrocarbonate: synthesis of 1,2-diamino-4-tosylaminobutane dihydrochloride

Abstract

Bamberger ring-cleavage acylation of N-tosylhistamine with di-t-butyl pyrocarbonate [ButOC(:O)–O–C(:O)OBut] in acetonitrile–aqueous potassium acetate leads to 3,4-bis(di-t-butoxycarbonylamino)but-3-enyl(tosyl)amine, which, after hydrogenation and treatment with hydrochloric acid, gives 1,2-diamino-4-tosylaminobutane dihyrochloride.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1985, 1133-1134

Ring opening of N-tosylhistamine with di-t-butyl pyrocarbonate: synthesis of 1,2-diamino-4-tosylaminobutane dihydrochloride

J. Altman, N. Shoef, M. Wilchek and A. Warshawsky, J. Chem. Soc., Chem. Commun., 1985, 1133 DOI: 10.1039/C39850001133

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