Classical optical resolution by fractional crystallization of diastereoisomeric salts obtained from the reaction of racemic N-t-butyl-(3a) and N-isopropyl-oxaziridine-3,3-dicarboxylic acid monomethyl ester (3b) with (R)-(+)- and (S)-(–)-1-phenylethylamine, followed by methylation of the optically active (3a) and (3b), affords chiral oxaziridines (2a) and (2b) whose asymmetry is due solely to the nitrogen atom.
M. Bucciarelli, A. Forni, I. Moretti, G. Torre, A. Prosyanik and R. G. Kostyanovsky, J. Chem. Soc., Chem. Commun., 1985, 998 DOI: 10.1039/C39850000998
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