Annelation reaction of levoglucosenone. Chiral intermediates for the synthesis of naphtho[2.3-c]pyran-5,10-quinone antibiotics
Abstract
Reaction of the anion of 3-cyano-4-methoxy-3H-isobenzofuran-1-one (4b) with levoglucosenone affords a chiral annelation products useful for the synthesis of naphtho[2.3-c]pyran-5,10-quinone antibiotics.