The crystal structures of (R)- and (S)-2,3-dihydroxypropylcobalamin; comparison with the structure of adenosylcobalamin

Abstract

The crystal structure of (R)- and (S)-2,3-dihydroxypropylcobalamin show Co–C_α–C_β angles of 119.6 ± 1.7 and 113.6 ± 2.1° and Co–C bond lengths of 2.002(23) and 2.079(30)Å, respectively; comparison with the structure of the B₁₂ coenzyme adenosylconbalamin suggests that the coenzyme's Co–CH₂–C angle of 125° is abnormal.