The polyether antibiotic ICI 139603 retains oxygen from acetate at C-1 and C-17, and from propionate at C-3 and C-21, after incorporation of [1-13C,1-18O2]acetate and [1-13C,1-18O2]propionate, and on this basis the tetrahydropyran and cyclohexane rings may be formed concertedly in a novel biosynthetic cyclisation.
A. K. Demetriadou, E. D. Laue, J. Staunton, G. A. F. Ritchie, A. Davies and A. B. Davies, J. Chem. Soc., Chem. Commun., 1985, 408 DOI: 10.1039/C39850000408
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