Oxygen binding to β-alkylimidazolyl-meso-tetra(α,α,α,α-o-pivalamidophenyl)porphinatoiron(II) embedded in a phospholipid bilayer under physiological conditions

Abstract

2-Mono(1-{N-[3-(2-methylimidazol-1-yl)propyl]carbamoyl}-2-(N-hexadecylcarbamoyl)ethyl-trans-acrylamido)-5,10,15,20-tetra-(α,α,α,α-o-pivalamidophenyl)porphinatoiron(II)(1a) was synthesized and solubilized in a physiological solution with phospholipid; the oxygen-binding rate constant rate constant and affinity were similar to those of erythrocytes in suspension.