Analytical investigations of cephalosporins. Part 9. Polarographic behaviour of some selected cephalosporins and assay of their formulations

Abstract

The polarographic properties of cephalothin, cephacetrile, cefamandole, cefamandole nafate and cefoperazone were investigated by using cathode-ray polarography (CRP) and differential-pulse polarography (DPP). The electroactive group present in the investigated cephalosporins in the R′ leaving group in CH₂R′, which is located at the 3-position. The electrochemical methods developed were applied to cephalosporins in dosage forms and a comparison was made with the Ni(II)-hydroxylamine method. The relative standard deviations obtained for the electroanalytical methods varied between 0.28 and 0.95% and for the comparative method between 0.54 and 1.91%.