2-Hydroxyarylglyoxylic acids (6) are readily prepared from the bromomagnesium salts of phenols (2) and oxalyl chloride (3) in toluene at room temperature. This procedure bypasses some of the inherent difficulties in the conventional Friedel–Crafts acylation procedures.
F. Bigi, G. Casiraghi, G. Casnati and G. Sartori, J. Chem. Soc., Perkin Trans. 1, 1984, 2655 DOI: 10.1039/P19840002655
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