Spirocyclic side-chain derivatives of penicillin and cephalosporin
Abstract
A series of two spirocyclic oxazolidinone derivatives of penicillin and four derivatives of cephalosporin have been prepared, as well as a benzoxazine conjugate of cephalosporin, with the object of freezing the conformation of the 6(7)-amide side-chain bearing a pendant aromatic ring. The antibacterial properties of these derivatives are discussed.