Issue 0, 1984

Pyrimidine derivatives and related compounds. Part 48. Uracil ring transformation: conversion of 5-nitrouracils into 5-carbamoyluracils

Abstract

1,3-Disubstituted 5-nitrouracils (1) react with malonamide in ethanolic sodium ethoxide to afford 1-substituted 5-carbamoyluracils (3)via rearrangement of the N(3)–C(4)–C(5) portion of the uracil. This ring transformation has been applied to the preparation of 2′,3′,5′-tri-O-acetyl-5-carbamoyluridine (8).

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1984, 1859-1861

Pyrimidine derivatives and related compounds. Part 48. Uracil ring transformation: conversion of 5-nitrouracils into 5-carbamoyluracils

K. Hirota, Y. Kitade and S. Senda, J. Chem. Soc., Perkin Trans. 1, 1984, 1859 DOI: 10.1039/P19840001859

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