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Issue 0, 1984
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Reaction of oxazolines with phosphorus oxychloride

Abstract

The reaction of simple aryloxazolines with phosphorus oxychloride in pyridine affords aryl nitriles. Alcohols, obtained by the reaction of ortho-lithiated oxazolines with ketones, under similar conditions, typically give substituted aryl nitriles. Exceptionally, further reaction can afford substituted indenone derivatives. Alcohols obtained by the reaction of ortho-lithiated oxazolines with aryl aldehydes react with phosphorus oxychloride in pyridine to give products by cleavage of the oxazoline ring.

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Article information


J. Chem. Soc., Perkin Trans. 1, 1984, 1253-1258
Article type
Paper

Reaction of oxazolines with phosphorus oxychloride

I. M. Dordor, J. M. Mellor and P. D. Kennewell, J. Chem. Soc., Perkin Trans. 1, 1984, 1253
DOI: 10.1039/P19840001253

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