A facile condensation reaction between bifunctional amines and carboxylic acid derivatives has been found to be very efficient for the formation of macrocyclic tetra-amide rings, and tetralactams with 33- to 37-membered rings were readily synthesized in good yields (60–90%).
Y. Okuno, K. Horita, O. Yonemitsu, K. Shibata, T. Amemiya and R. H. Holm, J. Chem. Soc., Perkin Trans. 1, 1984, 1115 DOI: 10.1039/P19840001115
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