New convenient versatile routes to the furan-3(2H)-one nucleus are described as exemplified by the synthesis of the two natural products bullatenone (1) and geiparvarin (2). The key step involves the hydration and cyclisation of the corresponding readily accessible acetylenic ketones which are best made by a Pd(II)–Cu(I)-catalysed coupling process.
R. F. W. Jackson and R. A. Raphael, J. Chem. Soc., Perkin Trans. 1, 1984, 535 DOI: 10.1039/P19840000535
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