Treatment of S-oxides of PS-5 and OA-6129 esters with nitromethane gives 2-(nitromethyl)carbapenems which are converted into nitrile oxides leading to isoxazolinyl, isoxazolinyl, or isoxadiazolinyl derivatives.
T. Yoshioka, K. Yamamoto, Y. Shimauchi, Y. Fukagawa and T. Ishikura, J. Chem. Soc., Chem. Commun., 1984, 1513 DOI: 10.1039/C39840001513
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