Biosynthesis of the polyether antibiotic monensin-A. Incorporation of [2-2H2]-, (R)-[2-2H1]- and (S)-[2-2H1]-propionate
Abstract
The incorporation of [2-2H2]- and (S)-[2-2H1]-propionate into monensin-A in cultures of Streptomyces cinnamonensis occurs with retention of label only at C(4) and C(6) in the antibiotic, whereas during the incorporation of (R)-[2-2H1]propionate the deuterium label is lost to the medium.