Nucleophiles react with 2-alkyl-3-trimethylsilylalk-3-enyl carbonyl compounds to afford ‘Cram’ products with high diastereoselectivity; this allows the stereoselective preparation of β-methylhomoally alcohols and β-hydroxy-α-methyl ketones.
F. Sato, M. Kusakabe and Y. Kobayashi, J. Chem. Soc., Chem. Commun., 1984, 1130 DOI: 10.1039/C39840001130
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