Highly diastereofacial selective addition of nucleophiles to 2-alkyl-3-trimethylsilyl alk-3-enyl carbonyl compounds. Stereoselective preparation of β-methylhomoallyl alcohols and β-hydroxy-α-methyl ketones
Abstract
Nucleophiles react with 2-alkyl-3-trimethylsilylalk-3-enyl carbonyl compounds to afford ‘Cram’ products with high diastereoselectivity; this allows the stereoselective preparation of β-methylhomoally alcohols and β-hydroxy-α-methyl ketones.