The introduction of a primary aminomethyl unit at the α-position of esters can be achieved in high yield by the silyl trifluoromethanesulphonate-catalysed reaction of ketene silyl acetals (2) with N,N-bis(trimethylsilyl)methoxymethylamine (1).
K. Okano, T. Morimoto and M. Sekiya, J. Chem. Soc., Chem. Commun., 1984, 883 DOI: 10.1039/C39840000883
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