Issue 11, 1984
From the journal:

Journal of the Chemical Society, Chemical Communications

Biosynthesis of LL-D253α in Phoma pigmentivora. Incorporation of 13C, 2H, and 18O enriched precursors

C. Rupert McIntyre,   Thomas J. Simpson,   L. A. Trimble  and  John C. Vederas  

Abstract

The incorporation of 13C, 2H, and 18O labelled acetates and 18O2 gas into LL-D253α(1), a chromanone metabolite of Phoma pigmentivora, and analyses of the enriched metabolites by 13C and 2H n.m.r. and mass spectroscopy indicate its formation from two preformed polyketide chains; evidence for the mechanism of formation of the chromanone ring is presented, and a cyclopropyl intermediate is proposed to account to account for the unique randomisation of label observed in the hydroxyethyl side chain.

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Article information

DOI
https://doi.org/10.1039/C39840000706
Article type
Paper

J. Chem. Soc., Chem. Commun., 1984, 706-709

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Biosynthesis of LL-D253α in Phoma pigmentivora. Incorporation of 13C, 2H, and 18O enriched precursors

C. R. McIntyre, T. J. Simpson, L. A. Trimble and J. C. Vederas, J. Chem. Soc., Chem. Commun., 1984, 706 DOI: 10.1039/C39840000706

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