The synthesis of 5-carboxymethylaminomethyluridine and 5-carboxymethylaminomethyl-2-thiouridine
Abstract
2′,3′-O-Isopropylideneuridine (1a) and 2′,3′-O-isopropylidene-2-thiouridine (1b) are converted in 4 steps, via the corresponding Mannich bases (2a) and (2b), into the modified nucleosides (5a) and (5b), respectively.