Synthetic transformations using iodotrimethylsilane: regiospecific deoxygenation of the dihydroxyacetone moiety at C-17 of corticoid steroids
Abstract
Corticoids having the dihydroxyacetone group C(17)(OH)–C(20)(O)-C(21)H2OH are regiospecifically converted into 21-hydroxy-20-ketones in high yields by treatment with iodotrimethylsilane.