The photochemical reactivity of chlorpromazine has been studied in an oxygenated solution containing micelles. The photochemical dehalogenation reaction which had previously only been observed in oxygen-free solutions was found to predominate. The relevance of this photoreaction and the micelle as a model for the in vivo phototoxicity of chlorpromazine is discussed.
G. A. Epling, C. Black and V. Rawal, J. Chem. Soc., Perkin Trans. 2, 1983, 1313 DOI: 10.1039/P29830001313
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