Incorporation studies on austdiol (1), a metabolite from Aspergillus ustus were carried out with [1,2-13C2]-acetate, [Me-13C]-, and [Me-2H3]-methionine. Specific incorporation of 4,6-dihydroxy-3,5-dimethyl-2-(2-oxopropyl)benzaldehyde (2) into austdiol (1) was demonstrated using 2H n.m.r. spectroscopy. The total synthesis of the ketoaldehyde (2), allowing the specific insertion of a label, is described.
L. Colombo, C. Gennari, G. Poli, C. Scolastico, F. Aragozzini and C. Merendi, J. Chem. Soc., Perkin Trans. 1, 1983, 2745 DOI: 10.1039/P19830002745
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