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Issue 0, 1983

The synthesis of 4-hydroxyandrost-4-ene-3,17-dione and other potential aromatase inhibitors

Abstract

We describe novel syntheses of 4-hydroxyandrost-4-ene-3,17-dione (Ia) and related compounds, some containing fluorine. In addition we provide further evidence of the general tendency of 2- and 6-substituted androst-4-ene-3,17-diones to undergo rearrangement reactions, and thus provide new routes to 6-fluoro- and 2,6-difluoro-derivatives. Several of these compounds are potent aromatase inhibitors.

Article information


J. Chem. Soc., Perkin Trans. 1, 1983, 2681-2685
Article type
Paper

The synthesis of 4-hydroxyandrost-4-ene-3,17-dione and other potential aromatase inhibitors

J. Mann and B. Pietrzak, J. Chem. Soc., Perkin Trans. 1, 1983, 2681 DOI: 10.1039/P19830002681

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