Selective Favorskii rearrangment of α,α,α′-dibromochlorocycloalkanones of medium ring size

Abstract

α,α,α′-Dibromochlorocycloalkanones of medium ring size have been prepared by treatment of chlorocycloalkanones with bromine and were separated by chromatorgraphy and then submitted to Favorskii reaction. The stereoisomeric reaction products have in each case been evaluated by gas chromatography and the selectivity of bromide elimination deduced.