Pyrolysis of protopine N-oxide (6) leads to the dibenzoxazacycloundecine (7) whose reduction with palladium catalyst affords (±)-corydalisol (2). Alternatively, zinc in acetic acid treatment of (7) leads to (±)-hypecorine (3) and (±)-corydalisol (2).
B. Gözler and M. Shamma, J. Chem. Soc., Perkin Trans. 1, 1983, 2431 DOI: 10.1039/P19830002431
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