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Issue 0, 1983
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Macrocyclic pyrrolizidine alkaloids. Synthesis and stereochemistry of (+)-dicrotaline (13β-hydroxy-13α-methyl-1,2-didehydrocrotalanine) and (+)-13-epi-dicrotaline

Abstract

Treatment of (+)-retronecine (1) with the trimethylsilyl ether of 3-hydroxy-3-methylglutaric anhydride gave a mixture of the 7- and 9-monoesters of (+)-retronecine (1). Lactonisation of this mixture was achieved using the corresponding pyridine-2-thiol esters to give (+)-dicrotaline (13β-hydroxy-13α-methyl-1,2-didehydrocrotalanine)(2) and (+)-13-epi-dicrotaline (3). The absolute configuration at C-13 in both compounds was established by a sequence of selective reactions on each epimer to yield optically active mevalonolactone.

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Article information


J. Chem. Soc., Perkin Trans. 1, 1983, 1819-1824
Article type
Paper

Macrocyclic pyrrolizidine alkaloids. Synthesis and stereochemistry of (+)-dicrotaline (13β-hydroxy-13α-methyl-1,2-didehydrocrotalanine) and (+)-13-epi-dicrotaline

K. Brown, J. A. Devlin and D. J. Robins, J. Chem. Soc., Perkin Trans. 1, 1983, 1819
DOI: 10.1039/P19830001819

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