Jump to main content
Jump to site search

Issue 0, 1983
Previous Article Next Article

Flavonoid epoxides. Part 17. Stereospecific synthesis and acid-catalysed rearrangement of aurone epoxides

Abstract

The configurations of 6-methoxyaurone epoxides were determined by direct epoxidation of the parent aurones (1) and (2) by m-chloroperbenzoic acid. trans-6-Methoxyaurone epoxide (3) was also synthesised indirectly through the intermediacy of the reduced ketone derivatives (4) and (5) of aurone (1) and aurone epoxide (3). m-Chloroperbenzoic acid was found to be complementary to alkaline hydrogen peroxide as an epoxidation agent for various aurones. Coumarins (10) were obtained on acid-catalysed rearrangement of aurone epoxides (8). The chlorohydrin derivative (11) of aurone epoxide (3), on treatment with alkali, gave the corresponding flavonol (12). Reduced aurone epoxide (5) gave aurone (1) on treatment with hydrochloric acid.

Back to tab navigation

Article type: Paper
DOI: 10.1039/P19830001151
J. Chem. Soc., Perkin Trans. 1, 1983, 1151-1155

  •   Request permissions

    Flavonoid epoxides. Part 17. Stereospecific synthesis and acid-catalysed rearrangement of aurone epoxides

    B. A. Brady, M. M. Healy and W. I. O'Sullivan, J. Chem. Soc., Perkin Trans. 1, 1983, 1151
    DOI: 10.1039/P19830001151

Search articles by author

Spotlight

Advertisements