Synthesis of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine and δ-(L-α-aminoadipyl)-L-cysteinyl-D-valylglycine
Abstract
An efficient synthesis of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV; 1) and δ-(L-α-aminoadipyl)-L-cysteinyl-D-valylglycine (ACVG; 2)via the protected tripeptide N-benzyloxycarbonyl-1-(p-nitrobenzyl)-δ-(L-α-aminoadipyl)-S-benzyl-L-cysteinyl-D-valine, benzhydryl ester (3) is described.