3-Methylcyclohex-2-enone derivatives as initiators of cyclisation. Part 1. Introduction and synthesis of 2-substituted 3-methylcyclohex-2-enones

Abstract

A series of C-2 substituted 3-methylcyclohex-2-enones has been prepared using the Hagemann ester route. A new synthesis of these compounds has been developed which involves the alkylation of the N,N-diethylaminoethyl ether of 1-hydroxy-5-methylcyclohexa-1,5-diene. The cyclohexenones have been converted into the corresponding α,β-epoxyketones using alkaline hydrogen peroxide.